ADAM33 基因S2 位點多態性與新疆維吾爾族人群哮喘的相關性研究_《中國呼吸與危重監護雜志》

作者：

桑珂 , 胡昕 , 王瓊 , 齊曼古力吾守爾

新疆醫科大學第一附屬醫院呼吸一科( 新疆烏魯木齊830054)通信作者: 齊曼古力· 吾守爾, E-mail: qimenw@ hotmail. com;

關鍵詞：

支氣管哮喘解整合素-金屬蛋白酶33 基因等位基因單核苷酸多態性

DOI：

DOI: 10 . 7507 /1671 -6205 . 20130106

視頻：

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目的探討解整合素-金屬蛋白酶33 基因S2 位點多態性與新疆維吾爾族人群支氣管哮喘的相關性。
方法納入131 例新疆維吾爾族支氣管哮喘患者( 病例組) 與90 例新疆維吾爾族健康體檢者( 對照組) , 應用聚合酶鏈和限制片段長度多態性( PCR-RFLP) 方法分析ADAM33 基因S2 位點單核苷酸多態性。
結果 ADAM33 基因S2 位點3 種基因型比較差異有統計學意義( X2 = 6. 065,P lt;0. 05) ; 2 組等位基因頻率比較差異有統計學意義(X2 =5. 255, P lt; 0. 025) ; S2 位點G 等位基因有增加患哮喘的風險( OR= 1. 616, P lt;0. 05) ; S2 位點的CG 基因型有增加患哮喘的風險( OR= 1. 351,P lt;0. 05) , 哮喘組ADAM33 基因S2 位點3 種基因型間FEV1% pred 和FVC% pred 比較差異有統計學意義( F =6. 248, P lt;0. 01; F = 7. 067, P lt; 0. 01) 。
結論 ADAM33 基因S2 位點與新疆維吾爾族支氣管哮喘具有明顯相關性, 并且增加維吾爾族人群患哮喘的風險。

引用本文： 桑珂,胡昕,王瓊,齊曼古力吾守爾. ADAM33 基因S2 位點多態性與新疆維吾爾族人群哮喘的相關性研究. 中國呼吸與危重監護雜志, 2013, 12(5): 442-445. doi: DOI: 10 . 7507 /1671 -6205 . 20130106 復制

1.	Primakoff P, Myles DG. The ADAM gene family: surface proteins with adhesion and protease activity. Trends Crenet, 2000, 16: 83 -87 .
2.	Van Eerdewegh P, Little RD, Dupuis J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.Nature, 2002, 418 : 426-430.
3.	中華醫學會呼吸病學分會哮喘學組. 支氣管哮喘防治指南. 中華結核和呼吸雜志, 2008, 31 : 177-185.
4.	Yoshinaka T, Nishii K, Yamada K, et al. Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity. Gene, 2002, 282( 1 /2) : 227-236.
5.	Dijkstra A, Vonk JM, Jongepier H, et al. Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex.Thorax, 2006 , 61: 105-110.
6.	Hirota T, Hasegawa K, Obara K, et al. Association between ADAM33 polymorphisms and adult asthma in the Japanese population. Clin Exp Allergy, 2006, 36: 884 -891.
7.	遲翔宇, 王學群, 王來城, 等. 支氣管哮喘患者ADAM33 基因S2位點多態性的研究. 臨床內科雜志, 2011, 28 : 47-49.
8.	Awasthi S, Tripathi P, Husain N, et al. Association of ADAM33 gene polymorphisms with asthma in Indian children. JHum Genet,2011, 56: 188-195 .
9.	de Faria IC, de Faria EJ, Toro AA, et al. Association of TGFbeta1,CDl4, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents. J Pediatr ( Rio J) ,.
10.	Matsusue A, Kiyohara C, Tanaka K, et al. ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children. Clin Biochem, 2009, 42: 477-483.
11.	Lind DL, Choudhry S, Ung N, et al. ADAM 33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med, 2003 , 168: 1312-1316.
12.	Lee JH, Park HS, Park SW, et al. ADAM33 polymorphism:association with bronchial hyper-responsiveness in Korean asthmatics. Clin Exp Allergy, 2004, 34: 860-865 .
13.	Kedda MA, Duffy DL, Bradley B, et al. ADAM33 haplotypes are associated with asthma in a large Australian population. Eur J Hum Genet, 2006 , 14 : 1027-1036.
14.	Hirota T, Hasegawa K, Obara K, et al. Association between ADAM33 polymorphisms and adult asthma in the Japanese population. Clin Exp Allergy, 2006, 36: 884 -891.
15.	Foley SC, Mogas AK, Olivenstein R, et al. Increased expression of ADAM33 and ADAM8 with disease progression in asthma. J Allergy Clin Immunol, 2007 , 119: 863-871.
16.	Sakagami T, Jinnai N, Nakajima T, et al. ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population. J Hum Genet, 2007, 52: 66-72 .
17.	Tripathi P, Awasthi S, Prasad R, et al. Association of ADAM33 gene polymorphisms with adult-onset asthma and its severity in an Indian adult population. J Genet, 2011, 90: 265-273.
18.	Fang Q, Zhao H, Wang A, et al. Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han Population. BMC Med Genet, 2011, 12: 133.
19.	, 84: 203-210 .

1. Primakoff P, Myles DG. The ADAM gene family: surface proteins with adhesion and protease activity. Trends Crenet, 2000, 16: 83 -87 .
2. Van Eerdewegh P, Little RD, Dupuis J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.Nature, 2002, 418 : 426-430.
3. 中華醫學會呼吸病學分會哮喘學組. 支氣管哮喘防治指南. 中華結核和呼吸雜志, 2008, 31 : 177-185.
4. Yoshinaka T, Nishii K, Yamada K, et al. Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity. Gene, 2002, 282( 1 /2) : 227-236.
5. Dijkstra A, Vonk JM, Jongepier H, et al. Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex.Thorax, 2006 , 61: 105-110.
6. Hirota T, Hasegawa K, Obara K, et al. Association between ADAM33 polymorphisms and adult asthma in the Japanese population. Clin Exp Allergy, 2006, 36: 884 -891.
7. 遲翔宇, 王學群, 王來城, 等. 支氣管哮喘患者ADAM33 基因S2位點多態性的研究. 臨床內科雜志, 2011, 28 : 47-49.
8. Awasthi S, Tripathi P, Husain N, et al. Association of ADAM33 gene polymorphisms with asthma in Indian children. JHum Genet,2011, 56: 188-195 .
9. de Faria IC, de Faria EJ, Toro AA, et al. Association of TGFbeta1,CDl4, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents. J Pediatr ( Rio J) ,.
10. Matsusue A, Kiyohara C, Tanaka K, et al. ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children. Clin Biochem, 2009, 42: 477-483.
11. Lind DL, Choudhry S, Ung N, et al. ADAM 33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med, 2003 , 168: 1312-1316.
12. Lee JH, Park HS, Park SW, et al. ADAM33 polymorphism:association with bronchial hyper-responsiveness in Korean asthmatics. Clin Exp Allergy, 2004, 34: 860-865 .
13. Kedda MA, Duffy DL, Bradley B, et al. ADAM33 haplotypes are associated with asthma in a large Australian population. Eur J Hum Genet, 2006 , 14 : 1027-1036.
14. Hirota T, Hasegawa K, Obara K, et al. Association between ADAM33 polymorphisms and adult asthma in the Japanese population. Clin Exp Allergy, 2006, 36: 884 -891.
15. Foley SC, Mogas AK, Olivenstein R, et al. Increased expression of ADAM33 and ADAM8 with disease progression in asthma. J Allergy Clin Immunol, 2007 , 119: 863-871.
16. Sakagami T, Jinnai N, Nakajima T, et al. ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population. J Hum Genet, 2007, 52: 66-72 .
17. Tripathi P, Awasthi S, Prasad R, et al. Association of ADAM33 gene polymorphisms with adult-onset asthma and its severity in an Indian adult population. J Genet, 2011, 90: 265-273.
18. Fang Q, Zhao H, Wang A, et al. Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han Population. BMC Med Genet, 2011, 12: 133.
19. , 84: 203-210 .

《中國呼吸與危重監護雜志》

ADAM33 基因S2 位點多態性與新疆維吾爾族人群哮喘的相關性研究

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《中國呼吸與危重監護雜志》

ADAM33 基因S2 位點多態性與新疆維吾爾族人群哮喘的相關性研究

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